Nature Biotechnology, 2026
Highly mutagenic continuous evolution in E. coli using a Φ29-based orthogonal replication system
Open PDFContinuous Evolution
Accelerating evolution to solve user-defined problems
We build and apply orthogonal replication systems that uncouple the mutagenesis of target genes from host viability, enabling the continuous mutagenesis and evolution of target genes at a million-times the genomic mutation rate. We aim to apply these accelerated evolution systems to address a range of evolutionary problems, from addressing fundamental evolutionary questions to evolving solutions to real-world problems in health and sustainability.
Join us at the Generative Biology Institute, EIT Oxford, Oxford, UK
Key Papers
Team
We are building a talented team from diverse backgrounds, with a shared interest in evolution as a problem-solving engine.
Fabian Rehm
Principal Investigator
Postdoc, MRC Laboratory of Molecular Biology, Cambridge, UK
PhD, The University of Queensland, Brisbane, Australia
Khoa Chung
Postdoctoral Scholar
DPhil, University of Oxford, Oxford, UK
Co-supervised with the Tian lab at GBI.
Collaborators
We are looking to set up collaborations, particularly with groups looking to apply our methodologies. Within the GBI, we have ongoing collaborations with the Tian lab.
We are looking to recruit postdoctoral researchers, research assistants, and graduate students.
Contact
We are always interested in scientific collaborations and trainee inquiries.
Location
Generative Biology Institute, Oxford Science Park, Oxford, UK
Opportunities
Postdoc , graduate student, and research assistant applications welcome.